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    Noyes dating endometrium

    During the 1st week of luteal activity, attention should be focused on changes occurring in gland epithelium: gland mitosis, pseudostratification of nuclei, basal vacuolation, and secretion.

    During the 2nd week , stromal changes (including edema), predecidual reaction, stromal mitosis, and leukocytic infiltration are the key criteria.

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    To ensure a maximum amount of tissue for morphological reading, the specimen should be placed on a piece of lens paper or some other adhesive tissue and then immersed in the fixative.

    As a result, morphologic evaluation of the endometrium is used in diagnostic evaluation of infertile patients to determine whether ovulation is occurring (Fig. Postovulatory estradiol amplifies the progesterone effect, and after withdrawal of both estradiol and progesterone, the endometrial mucosa breaks down and regenerates within the period of menstruation.

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    Infertility affects approximately 10-15% of reproductive-aged couples.

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